Tuesday, 30 August 2016

Why some patients respond to immune therapy- and others unfortunately don't.

Immune therapies are making a huge difference in Melanoma. For the first time, there is hope for survival 
in a disease previously infamously famous for its poor prognosis once the cancer has spread. 
Unfortunately, not all Melanoma patients respond to immune therapy and finding out why- and how to change that- is one of the big next challenges for anyone in Melanoma.

This is now an interesting article (free pdf under the link) by Kim and Chen on why some patients respond to PD1/ PDL1 blockage and others don't.

They start with the 'cancer immunity cycle' first published by others to show how the cancer and the body's immune system interact: 

And then go through what can go wrong at each of these 7 steps. 

You can listen to a really good comment on that paper by David Kerr here . 

And the link to the full paper again: http://annonc.oxfordjournals.org/content/27/8/1492.full.pdf+html